Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin
نویسندگان
چکیده
منابع مشابه
Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA
Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, its molecular mechanism for recognizing Le(b) antigens remains unknown. We prese...
متن کاملStructural basis of Lewis antigen binding by the Helicobacter pylori adhesin BabA
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca R&D, Alderley Park, Cheshire SK10 4TG, UK. Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca R&D, Darwin Building, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK. Pharmaceutical Development, A...
متن کاملStreptococcus mutans strains harboring collagen-binding adhesin.
A previously unidentified 120-kDa protein was detected in Streptococcus mutans strain Z1 and was involved in the cold-agglutination of the strain. We have identified the gene, designated cnm, as being involved in the agglutination of strain Z1 following random mutagenesis. The amino acid sequence of the deduced Cnm protein exhibited high similarity to those of collagen-binding adhesins from sta...
متن کاملStreptococcus gordonii Hsa environmentally constrains competitive binding by Streptococcus sanguinis to saliva-coated hydroxyapatite.
Competition between pioneer colonizing bacteria may determine polymicrobial succession during dental plaque development, but the ecological constraints are poorly understood. For example, more Streptococcus sanguinis than Streptococcus gordonii organisms are consistently isolated from the same intraoral sites, yet S. gordonii fails to be excluded and survives as a species over time. To explain ...
متن کاملStructural Studies of the Surface Adhesin SspB from Streptococcus gordonii
Surface proteins on microorganisms that build up the oral biofilm are key players in the formation of the biofilm. Antigen I/II proteins are surface adhesins found on virtually all oral streptococci and share a conserved multi-domain architecture. These adhesins bind surface components on other bacteria and on host cells. Thus, they are crucial for the development of the biofilm. The objective ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.701425